Determination of Haptoglobin Genotype in an Iranian Population with Idiopathic Generalized Epilepsy

Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.

BACKGROUND Haptoglobin (Hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. Haptoglobin expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or Hp2-1 ...

determination of haptoglobin genotype in an iranian population with idiopathic generalized epilepsy

background: haptoglobin (hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. it displays in three common phenotypes, hp1-1, hp2-1, and hp2-2. proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. haptoglobin expressed by the hp2-2 genotype has lower hemoglobin-binding capacity than hp1-1 or hp2-1...

Association of CD24V/V Genotype with Susceptibility and Progression of Multiple Sclerosis in Iranian Population

A single nucleotide polymorphism (SNP) in CD24 has been associated with multiple sclerosis (MS) in a population based study. This SNP results in the replacement of alanine (CD24A) by valine (CD24V) at amino acid 57 in the resulting polypeptide chain. In the current study, the genotyping of this SNP and its contribution to MS in 217 patients and 200 healthy individuals of an Iranian population w...

Investigating Relationship of positive Family Historypattern and the incidence of idiopathic epilepsy in patients with epilepsy

Estimating the Optimal Dosage of Sodium Valproate in Idiopathic Generalized Epilepsy with Adaptive Neuro-Fuzzy Inference System

Introduction: Epilepsy is a clinical syndrome in which seizures have a tendency to recur. Sodium valproate is the most effective drug in the treatment of all types of generalized seizures. Finding the optimal dosage (the lowest effective dose) of sodium valproate is a real challenge to all neurologists. In this study, a new approach based on Adaptive Neuro-Fuzzy Inference System (ANFIS) was pre...

Corpus callosotomy in refractory idiopathic generalized epilepsy

RATIONALE A small percentage of patients with idiopathic generalized epilepsy (IGE) do not respond to medical therapy. Generalized tonic-clonic (GTC) seizures are especially debilitating and can be associated with severe injuries. The benefit, safety and effect of corpus callosotomy (CC) in patients with IGE have not been studied. METHODS We reviewed patients with presumed IGE who underwent C...